The Basilica Santuario di Maria Santissima del Suffragio in Grotte di Castro was built in 1625 by the architect Girolamo Rainaldi and completed in 1672 by Andrea Selvi.
The church has a Latin cross plan and side chapels, enriched by works of inestimable value: the painting of the Holy Crucifix between St Francis of Assisi and St Mary Magdalene, from the school of Guido Reni; the Baptism of Jesus, from the school of Pietro da Cortona; the Nativity of St John the Baptist and the Beheading by Luigi Fontana and the precious wooden statue of the Madonna del Suffragio from the early 17th century, to which the church is dedicated.